On Oct. 11, 2023, EPA finalized a rule under the Toxic Substances Control Act (TSCA) to create the largest-ever public database of per- and polyfluoroalkyl substances (PFAS) manufactured and used in the US. PFAS can pose a danger even in small quantities with exposure linked to kidney, prostate, and testicular cancer. The final rule expanded the definition of PFAS to include 41 additional substances, and required manufacturers that produce or have produced PFAS since Jan. 2011 to provide data on PFAS use, production volumes, disposal, exposures, and hazards. EPA planned to use the data to inform future rulemakings and enforcement. The rule went into effect Nov. 13, 2023. In the rule, EPA noted it could not perform an environmental justice analysis due to the lack of data on every exposure source.
On Nov. 13, 2025, EPA proposed to roll back parts of its PFAS reporting requirements. Under the proposed rule, chemical manufacturers will no longer need to report on PFAS that were made for research and development purposes or that were used as a minor ingredient, meaning 0.1% or less of an item or mixture. EPA Administrator, Lee Zeldin, said the proposal would lessen regulatory burdens on American businesses. EPA also requested comment on implementing a production volume threshold and limiting reporting requirements to only PFAS with a Chemical Abstracts Service Registry Number (CASRN), a TSCA Accession Number, or a Low-Volume Exemption number. Comments can be submitted until Dec. 29, 2025.